#5510 CKD-ASSOCIATED PRURITUS SEVERITY AND ITS ASSOCIATION WITH BODY DISTRIBUTION AND EQ-5D HEALTH-RELATED QUALITY OF LIFE IN HAEMODIALYSIS PATIENTS

Abstract Background and Aims Chronic Kidney Disease associated pruritus (CKD-aP) is common affecting 40% of people with kidney disease receiving dialysis. It decreased health-related quality life (HRQoL) as assessed using disease-specific instruments. A better understanding how the severity CKD-aP related to distribution affected body parts generic HRQoL EQ-5D instrument could improve identification, assessment, treatment including advocating for access new therapies. Method Prevalent in-centre haemodialysis patients from five centres prospectively completed EQ-5D-5L questionnaires, severity-based worst itch numeric rating scale (WI-NRS) multi-dimensional 5-D specific Latent class mixture models were used identify clusters similarly through map measures utility value (1 being perfect health 0 dead, heavily skewed). Patient demographics, comorbidities, dialysis prescription anti-pruritus medications collected. Results Pruritus data on 485 respondents obtained. No was reported in 164 (33.8%), 117 (24.1%) reporting mild, 123 (25.4%) moderate 81 (16.7%) severe pruritus. Commonly included groin (22%), upper arms (21%), forearms (11%), back (10%). Anti-pruritus medication use across (none severe) 40.6%, 38.5%, 36.6% 55.6%, varied by part 38.8%, 21.0% 14.5% those limbs, lower legs respectively. analysis identified three groups who had progressively worsening number affected, but relatively constant (left-hand figure) reduction similar. Although WI-NRS instruments correlated each other, only a strong relationship EQ-5D-3L: Controlling age, sex, diabetes, years dialysis, predicted dropped linearly 0.69 0.41 (right-hand figure). Conclusion Contemporary UK shows remains highly prevalent amongst failure Severe commonly despite half antipruritic medication, illustrating high unmet need likely undertreated. there similar reductions HRQoL, whose may be other High none or mild represent more severely individuals benefiting these drugs cross-sectional nature study means no have past which resolved response prescribed analyses. Overall, it worsens appears affect parts. that include domains are broader than just closely approximate measure therefore strongly advocate treating this unpleasant condition. Funded CSL Vifor.